Comparação do perfil de dissolução de comprimidos de lamotrigina de referência, genéricos e similares disponíveis comercialmente no Peru e no Brasil
Article Sidebar
Main Article Content
Abstract
Comparison dissolution profile between drugs is crucial to determining the interchangeability. This study compared the in vitro dissolution profiles of drugs containing 50 mg of lamotrigine in tablet form: three Brazilian pills (reference, generic, and similar) and three Peruvian pills (two similar and one generic) according to the official dissolution test guidelines. The results obtained from media with pH 1.2 and 4.5 indicate that all tested samples met the specified standards. However, in the dissolution medium at pH 6.8, only one of the lamotrigine tablets samples did not give a satisfactory result. These data helped me understand the possibility of interchangeability between Brazilian and Peruvian lamotrigine pills. They highlighted the impact of more research in this field to strengthen the discussions on guideline standardization across the countries to ensure the same bioavailability and efficacy for traveling patients.
Article Details
Section
This work is licensed under a Creative Commons Attribution 4.0 International License.
• The author (s) warrant that the contribution is original and unpublished and that it is not in the process of being evaluated in other journal (s);
• The journal is not responsible for the opinions, ideas and concepts issued in the texts, as they are the sole responsibility of the author (s);
• Publishers have the right to make textual adjustments and to adapt the article to the rules of publication.
Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg publish in institutional repository or as book chapter), with acknowledgment of authorship and initial publication in this journal.
Authors are allowed and encouraged to publish and distribute their work online (eg in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and citation of the published work (See The Effect of Free Access) at http://opcit.eprints.org/oacitation-biblio.html