Exploring the staphylococcus aureus in patients infected of the tertiary-care university hospital: results of the retrospective cohort study

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Maria Clara Bisaio Quillici
Claudete Freitas
Cristiane Silveira de Brito
Iara Rossi Gonçalves
Lizandra Ferreira de Almeida e Borges
Melina Lorraine Ferreira
Paola Amaral de Campos
Rosineide Marques Ribas
Juliana Pena Porto

Resumo

Objective: To establish a baseline of knowledge regarding about inappropriate therapy, virulence and resistance in a cohort of patients infected with S. aureus. Methods: Retrospective cohort study in tertiary-care university hospital was employed to evaluate the risk factors and the impact of inappropriate therapy among patients with Staphylococcus aureus infections, resistance and virulence. To assess the presence of the genes was performed PCR. Results: Patients with MRSA were older and hospitalized 17 days longer than those with MSSA infection, which were in ICU with a bloodstream infection. 50.0% received inadequate antibiotic therapy and we found virulence factors associated with MRSA (mecA, LukS, fnbB and clfA genes). Conclusion: These data show that surveillance studies related to Staphylococcus aureus infections remain essential to identify resistance and inform policy on resistance.

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Quillici, M. C. B., Freitas, C., de Brito, C. S., Gonçalves, I. R., e Borges, L. F. de A., Ferreira, M. L., de Campos, P. A., Ribas, R. M., & Porto, J. P. (2021). Exploring the staphylococcus aureus in patients infected of the tertiary-care university hospital: results of the retrospective cohort study. Revista Brasileira Multidisciplinar, 24(1). https://doi.org/10.25061/2527-2675/ReBraM/2021.v24i1.926
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