Hipertensão arterial como fator de risco para doenças ateroscleróticas
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Abstract
ABSTRACT
Hypertension is a chronic, slowly evolving, silent disease. The pathology generates a dysfunction in arterial endothelial tissue, causing significant physiological and morphological changes in the vascular system. Hypertension is considered one of the main risk factors for the development of atherosclerotic diseases such as acute myocardial infarction, ischemic stroke, and peripheral arterial disease, pathologies with high mortality rates and sequelae. The aim of this work was to identify the influence of hypertension on the development of these three atherosclerotic pathologies. Data analysis was performed using the chi-square method. The study included 137,211 patients with atherosclerotic disease, with a history of hypertension or not. Statistical analysis indicated that 65.8% of patients with ischemic stroke, 60.1% with acute myocardial infarction, and 57.7% with peripheral arterial disease had a history of hypertension. The work evidenced arterial hypertension as an important predictor risk factor for the development of atherosclerotic diseases, present in more than half of the analyzed patients. The results suggest that patients with arterial hypertension would have a higher propensity for the development of ischemic stroke.
Keywords
hypertension. atherosclerosis. acute myocardial infarction, ischemic stroke. peripheral arterial disease.
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References
REFERÊNCIAS
BENJAMIN, E.J.; BLAHA, M.J.; CHIUVE, S.E.; CUSHMAN, M.; DAS, S.R.; DEO, R.; DE FERRANTI, S.D.; FLOYD, J.; FORMAGE, M.; GILLESPIE, C.; ISASI, C.R.; JIMÉNEZ, M.C.; JORDAN, L.C.; JUDD, S.E.; LACKLAND, D.; LICHTMAN, J.H.; LISABETH, L.; LIU, S.; LONGENECKER, C.T.; MACKEY, R.H.; MATSUSHITA, K.; MOZAFFARIAN, D.; MUSSOLINO, M.E.; NASIR, K.; NEUMAR, R.W.; PALANIAPPAN, L.; PANDEY, D.K.; THIAGARAJAN, R.R.; REEVES, M.J.; RITCHEV, M.; RODRIGUEZ, C.J.; ROTH, G.A.; ROSAMOND, W.D.; SASSON, C.; TOWFIGHI, A.; TSAO, C.W.; TURMER, M.B.; VIRANI, S.S.; VOEKS, J.H.; WILLEY, J.Z.; WILKINS, J.T.; WU, J.H.; ALGER, H.M.; WONG, S.S.; MUNTENER, P. Heart Disease and Stroke Statistics Update – 2017: A Report by the American Heart Association. Circulation. v. 135, n. 10, p. 146 – 603, 2017. Doi: 10.1161 / CIR.0000000000000485.
CRIQUI, M. H.; ABOYANS, V. Epidemiology of peripheral artery disease. Circulation Research. v. 116, n. 9, p. 1509-1526, 2015. Doi: 10.1161 / CIRCRESAHA.116.303849. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25908725/. Acesso em: 22 set. 2021.
FEKADU, G.; CHELKEBA, L.; KEBEDE, A. Risk factors, clinical presentations and predictors of stroke among adult patients admitted to stroke unit of Jimma university medical center, south west Ethiopia: prospective observational study. BioMed Central Neurology, v. 19, n. 1, p. 187, 2019. Doi: 10.1186 / s12883-019-1409-0. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31390995/. Acesso em: 24 set. 2021.
FOROUZANFAR, M. H.; ALEXANDER, L.; ANDERSON, H.R.; BACHMAN, V.F.; BIRVUKOV, S.; BRAUER, M.; BURNETT, R., CASEY, D.; COATES, M.M.; COHEN, A.; DELWICHE, K.; ESTEP, K.; FROSTAD, J.J.; ASTHA, K.C.; KYU, H.H.; MORADI-LAKEH, M. Comparative global, regional and national risk assessment of 79 behavioral, environmental, occupational and metabolic hazards or risk groups in 188 countries, 1990 – 2013: A systematic review for the Global Burden of Disease Study 2013. Lancet. v. 386, n. 10010, p. 2287–2323, 2015. Doi: 10.1016 / S0140-6736 (15) 00128-2. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26364544/. Acesso em: 20 set. 2021.
HERLITZ, J. KARLSON, B.W.; RICHTER, A.; WIKLUND, O., JABLONSKIENE, D.; HLALMARSON, A. Prognosis in hypertensives with acute myocardial infarction. Journal Hypertensive. v. 10, n. 10, p.1265 – 1271, 1992. Doi: 10.1097 / 00004872-199210000-00022 . Disponível em: https://europepmc.org/article/med/1335010. Acesso em: 25 set. 2021.
KANNEL, W. B. Contribution of the Framingham study to preventive cardiology. Journal of the American College of Cardiology v. 15, n. 1, p. 206-211, 1990. Doi: doi.org/10.1016/0735-1097(90)90203-2. Disponível em: https://www.sciencedirect.com/science/article/pii/0735109790902032. Acesso em: 22 set. 2021.
MAKDISSE, M.; PEREIRA, A.C.; BRASIL, D.P.; BORGES, J.L.; MACHADO-COELHO, G.L.L.; KRIEGER, J.E.; NETO, R.M.N.; CHAGAS, A.C.P. Prevalence and risk factors associated with peripheral arterial disease in the hearts of Brazil project. Arquivos Brasileiros Cardiologia. v. 91, n. 6, p. 402-401, 2008. Doi: 10.1590 / s0066-782x2008001800008. Disponível em: https://pubmed.ncbi.nlm.nih.gov/19142364/. Acesso em: 25 set. 2021.
MENDIS, S.; PUSKA, P.; NORRVING, B. Eds. (2011) Global Atlas on cardiovascular Disease Prevention and Control. Organização Mundial da Saúde, Genebra.
MLACO, A.; MLACO, N.; MEKIC, M.; DZUBUR, A. Epidemiology of hospitalized patients with peripheral arterial disease in Bosnia and Herzegovina. Medicinski Glasnik (Zenica). v. 18, n. 2. p. 468-474, 2021. Doi: 10.17392 / 1397-21. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34308619/. Acesso em: 20 set. 2021.
MURAKAMI, K.; ASAYAMA, K.; SATOH, M.; INOUE, R.; TSUBOTA-UTSUGI, M.; HOSAKA, M.; MATSUDA, A.; NOMURA, K.; MURAKAMI, T.; KIKUYA, M., METOKI, H.; IMAI, Y.; OHKUBO, T. Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study. Journal of atherosclerosis and thrombosis. v. 24, n. 3, p. 290-300, 2017. Doi: 10.5551 / jat.35766. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383545/. Acesso em: 23 set. 2021.
OWOLABI, M.O.; SARFO, F.; AKINYEMI, R.; GEBREGZIABHER, M.; AKPA, O.; AKPALU, A. Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study. The Lancet Global Health. v. 6, n. 4, p.436-446, 2018. Doi: 10.1016 / S2214-109X (18) 30002-0. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29496511/. Acesso em: 24 set. 2021.
ROSINI, N.; MACHADO, M. J.; XAVIER, H.T. Study of the prevalance and multiplicity of cardiovascular risk factors in hypertensive patients in the city of Brusque, SC. Arquivos Brasileiros de Cardiologia. v. 86, n. 3, p. 219-22, 2006. Doi: https://doi.org/10.1590/S0066-782X2006000300010. Disponível em: https://www.scielo.br/j/abc/a/pkfcPdhG7Z74PbK98HVmYDd/?lang=pt. Acesso em: 26 set. 2021.
SARATZIS, A.; JASPERS, N.E.M.; GWILYM, B.; THOMAS, O.; TSUI, A.; LEFROV, R.; PARKS, M.; HTUN, V.; MERA, Z.; THATCHER, A.; BOSANQUET, D.; FORSYTHE, R.; BENSON, R.; DATTANI, N.; DOVELL, G.; LANE, T.; SHALHOUB, J.; SIDLOFF, D., VISSEREN, F.L.J.; DORRESTEIJN, J.A.N.; RICHARDS, T. Observational study of the medical management of patients with peripheral artery disease. British Journal of Surgery. v. 106, n. 9, p. 1168-1177, 2019. Doi: 10.1002 / bjs.11214. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31259387/#affiliation-1. Acesso em: 20 set. 2021.
SEALY-JEFFERSON, S.; WING, J.J.; SÁNCHEZ, B.N.; BROWN, D.L.; MEURER, W.J.; SMITH, M.A.; MORGENSTERN, L.B.; LISABETH, L.D. Age- and ethnic-specific sex differences in stroke risk. Gender Medicine. v. 9, n. 2, p.121-128, 2012. Doi: 10.1016 / j.genm.2012.02.002. Disponível em: https://pubmed.ncbi.nlm.nih.gov/22445684/. Acesso em: 21 set. 2021.
SHIRAISHI, J.; KOHNO, Y.; YAMAGUCHI, S.; ARIHARA, M.; HADASE, M.; HYOGO, M.; YAGI, T.; SHIMA, T.; SAWADA, T.; TATSUMI, T.; AZUMA, A.; MATSUBARA, H. AMI-Kyoto Multi-Center Risk Study Group. Acute myocardial infarction in young Japanese adults. Circulation Journal. v. 69, n. 12, p. 1454-1458, 2005. Doi: https://doi.org/10.1253/circj.69.1454. Disponível em : https://www.jstage.jst.go.jp/article/circj/69/12/69_12_1454/_article. Acesso em: 23 set. 2021.
SIM, D. S.; JEONG, M. H. Differences in the Korea Acute Myocardial Infarction Registry Compared with Western Registries. Korean Circulation Jounal. v. 47, n. 6, p. 811-822, 2017. Doi: 10.4070 / kcj.2017.0027. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711672/. Acesso em: 23 set. 2021.
SKÓRKOWSKA-TELICHOWSKA, K.; KROPIELNICKA, K.; BULINSKA, K.; PILCH, U.; WOZNIEWSKI, M.; SZUBA, A.; JASINSKI, R. Insufficient modification of atherosclerosis risk factors in PAD patients. Advances in Clinical and Experimente Medicine.v. 27, n. 6, p. 819-826, 2018. Doi: 10.17219 / acem / 68983. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30059197/. Acesso em: 20 set. 2021.
SOLER, E. P.; RUIZ, V. C. Epidemiology and risk factors of cerebral ischemia and ischemic heart diseases: similarities and differences. Current Cardiology Reviews. v. 6., n. 3, p. 138-49, 2010. Doi: 10.2174 / 157340310791658785. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21804773/. Acesso em: 24 set. 2021.
WILLIAMS, B. The year in hypertension. Journal American College Cardiology. v. 51, n. 18, p. 66-73, 2010. Doi: 10.1016 / j.jacc.2008.03.010. Disponível em: https://pubmed.ncbi.nlm.nih.gov/18452788/. Acesso em: 22 set. 2021.
WILLEY, J.; MENTIAS, A.; VAUGHAN-SARRAZIN, M.; McCOY, K.; ROSENTHAL, G.; GIROTRA, S. Epidemiology of lower extremity peripheral artery disease in veterans. Journal of Vascular Surgery. v. 68, n. 2, p.527-535, 2018. Doi: 10.1016 / j.jvs.2017.11.083. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29588132/. Acesso em: 21 set. 2021.
WOLF, P.; D'AGOSTINO, R.B.; BELANGER, A.J.; KANNEL, W.B. "Probability of stroke: a risk profile from the Framingham study". Stroke. v. 32, n. 22, p. 312-318, 1991. Doi: 10.1161 / 01.str.22.3.312. Disponível em: https://pubmed.ncbi.nlm.nih.gov/2003301/. Acesso em: 23 set. 2021.
YANDRAPALLI, S.; NABORS, C.; GOYAL, A.; ARONOW, W.S.; FRISHMAN, W.H. Modifiable Risk Factors in Young Adults With First Myocardial Infarction. Journal of American College Cardiology. v. 73, n. 5, p. 573-584, 2019. Doi: 10.1016 / j.jacc.2018.10.084. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30732711/. Acesso em 25 set. 2021.
ZHUO, Y.; WU, J.; QU. Y.; YU, H.; HUANG, X.; ZEE, B.; LEE, J.; YANG, Z. Clinical risk factors associated with recurrence of ischemic stroke within two years: A cohort study. Medicine (Baltimore), v. 99, n. 26, p. e20830, 2020. Doi: 10.1097 / MD.0000000000020830. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328985/. Acesso em: 23 set. 2021.