Homeopatia para o controle da hiperacidez gástrica: revisão sistemática da literatura

Main Article Content

Bruna Galdorfini
Renan Françon Araújo Ventura

Abstract

Peptic ulcer, gastroesophageal reflux, ulcers induced by the use of non-steroidal anti-inflammatory drugs, Zollinger-Ellison syndrome and ulcers resulting from H. pylori infection are conditions in which disorders related to gastric acid secretion occur. Patients report pain and discomfort, in addition to the observation of severe damage to the gastric mucosa that, therefore, need to be treated. Treatments are mainly based on the use of proton pump inhibitors, which include omeprazole and esomeprazole, but despite their undeniable efficacy, they have been shown to cause severe adverse reactions, especially in conditions of prolonged use. Thus, these data point to the need for effective yet safe therapeutic options, even in conditions where chronic use is required. In this context, this study aimed to present, through a systematic review of the literature, homeopathic resources that can be used to control gastric hypersecretion, mainly aiming at presenting a therapeutic alternative to patients who require the chronic use of drugs for this purpose. Homeopathic medicines such as Nux Vomica, Phosphorus, Kali Bichromicum, Lycopodium Clavatum, Carbo Veg, Hydrastis Canadensis, Graphites and Conium maculatum have been described in the literature as efficient for these pathologies. However, this work points to the need for more clinical studies, allowing the publication of original articles, which demonstrate the effectiveness of these drugs, since, considering the studied disorder, the literature is extremely scarce and quite generic, based mainly on reviews of the literature, based only on consultation on medical matters, which despite their importance, require complementation with more current studies, increasing the reliability of homeopathy both for health professionals and for patients.

Downloads

Download data is not yet available.

Article Details

How to Cite
Chiari-Andréo, B. G., & Ventura, R. F. A. . (2022). Homeopatia para o controle da hiperacidez gástrica: revisão sistemática da literatura. Revista Brasileira Multidisciplinar, 25(3), 155-174. https://doi.org/10.25061/2527-2675/ReBraM/2022.v25i3.1549
Section
Artigos de Revisão
Author Biographies

Bruna Galdorfini, Universidade de Araraquara - UNIARA

Departamento de Ciências Biológicas e da Saúde, Universidade de Araraquara – UNIARA.

Renan Françon Araújo Ventura, Universidade de Araraquara – UNIARA

Departamento de Ciências Biológicas e da Saúde, Universidade de Araraquara – UNIARA.

References

AHRENS, D.; BEHRENS, G.; HIMMEL, W.; KOCHEN, M. M.; CHENOT, J. F. Appropriateness of proton pump inhibitor recommendations at hospital discharge and continuation in primary care. International Journal of Clinical Practice, v. 66, n. 8, p. 767-773, 2012.

BADIOLA, N.; ALCALDE, V.; PUJOL, A.; MÜNTER, L. M.; MULTHAUP, G.; LLEÓ, A.; COMA, M.; SOLER-LÓPEZ, M.; ALOY, P. The proton-pump inhibitor lansoprazole enhances amyloid beta production. PLoS One, v. 8, n. 3, 2013.

BAGOT, J.L.; THEUNISSEN, I.; SERRAL, A. Perceptions of homeopathy in supportive cancer care among oncologists and general practitioners in France. Support Care Cancer, v. 29, p. 5873–5881, 2021.

BLOOM, S.R.; MORTIMER, C.H.; THORNER, M.O.; BESSER, G.M.; HALL, R.; GOMEZ-PAN, A. et al. Inhibition of gastrin and gastric-acid secretion by growth-hormone release inhibiting hormone. Lancet, v.2, p.1106-1109, 1974.

BOCKERSTETT, K. A.; OSAKI, L. H.; PETERSEN, C. P.; CAI, C. W.; WONG, C. F.; NGUYEN, T. M.; FORD, E. L; HOFT, D. F.; MILLS, J. C.; GOLDENRING, J. R.; DIPAOLO, R. J. Interleukin-17a promotes parietal cell atrophy by inducing apoptosis. Cellular and Molecular Gastroenterology and Hepatology, v. 5, p. 678-690, 2018.

CAIRO, N. Guia de medicina homeopática. 25.ed. São Paulo: Cienbook, 2020.

CATS, A.; SCHENK, B. E.; BLOEMENA, E.; ROOSEDAAL, R.; LINDEMAN, J.; BIEMOND, I.; KLINKENBERG-KNOL, E. C.; MEUWISSEN, S. G.; KUIPERS, E. J. Parietal cell protrusions and fundic gland cysts during omeprazole maintenance treatment. Human Pathology, n. 31, p. 684–690, 2000.

CFF - Guia de prática clínica: sinais e sintomas do TGI l: azia (acidez/pirose) e dispepsia. Conselho Federal de Farmácia. – Brasília: Conselho Federal de Farmácia, 2020. 200 p. Disponível em: https://www.cff.org.br/userfiles/Guia%20-%20AZIA(1).pdf. Acesso em: 3 Fev. de 2022.

CHU, S.; SCHUBERT, M.L. Gastric secretion. Curr Opin Gastroenterol, v.29, p.636-641, 2013.

CUKACI, C.; FREISSMUTH, M.; MANN, C.; MARTI, J.; SPERL, V. Against all odds—the persistent popularity of homeopathy. Wien Klin Wochenschr, v. 132, p. 232–242, 2020.

FIOR, T.; PATEL, N. Severe ulcerative gastritis in a 53-year-old woman a homeopathic case report. American Journal of Homeopathic Medicine, v. 111, p. 20-26, 2018.

FISHER, P. What is Homeopathy? An Introduction. Front. Biosci. (Elite Ed), v. 4, n. 5, p. 1669–1682, 2012.

FOSSMARK, R.; MARTINSEN, T. C.; WALDUM, H. L. Adverse effects of proton pump inhibitors -evidence and plausibility. International Journal of Molecular Sciences, v. 20, n. 20, 2019.

GALVÃO, T.F.; PANSANI, T.S.A.; HARRAD, D. Principais itens para relatar revisões sistemáticas e meta-análises: a recomendação Prisma. Epidemiol. Serv. Saúde. v. 24, n. 2, p. 335-42, 2015.

GARTNER, L. P.; HIATT, J. L. Tratado de histologia em cores. 3. ed. Rio de Janeiro: Guanabara Koogan, 2007.

GOSAVI, T.P.; GHOSH, P.; KANDHARE, A.D.; KUMAR, V.S.; ADIL, M.; RAJMANE, A.R.; BODHANKAR, S.L. Therapeutic effect of H. pylori nosode, a homeopathic preparation in healing of chronic H. pylori infected ulcers in laboratory animals. Asian Pacific Journal of Tropical Disease, v. 2, n. 2, p. S603-S611, 2012.

HATNOORKAR, S.A.; RAJPAL, C. Homoeopathy and acid peptic disorder. Journal of Medical and Pharmaceutical Innovation, v. 9, n. 45, p. 11-14, 2022.

HAYASHIBARA, T. Hemolytic anemia and thrombocytopenia associated with anti-omeprazole antibody. Rinsho Ketsueki, v.39, p. 447–452, 1998.

IMHANN, F.; BONDER, M. J.; VICH VILA, A.; FU, J.; MUJAGIC, Z.; VORK, L.; TIGCHELAAR, E. F.; JANKIPERSADSING, S. A.; CENIT, M. C.; HARMSEN, H. J.; DIJKSTRA, G.; FRANKE, L.; XAVIER, R. J.; JONKERS, D.; WIJMENGA, C.; WEERSMA, R. K.; ZHERNAKOVA, A. Proton pump inhibitors affect the gut microbiome. Gut, v. 65, n. 5, p. 740–748, 2016.

JUNQUEIRA, L. C.; CARNEIRO, J. Histologia básica: texto/atlas. Rio de Janeiro: Guanabara Koogan, 2008.

KASPRZAK, A. Somatostatin and its receptor system in colorectal cancer. Biomedicines, v. 9, n.11, 2021.

KIM, D. U.; MOON, J. H.; LEE, Y. H.; PAIK, S. S.; KIM, Y.; KIM, Y. J. Analysis of somatostatin-secreting gastric delta cells according to upper abdominal symptoms and Helicobacter pylori infection in children. Pediatric Gastroenterology, Hepatology & Nutrition. v. 23, n. 3, 2020.

KUSHWAHA, P.; SHARMA, S.K. Homeopathic management of peptic ulcer: a review. Journal of Medical and Pharmaceutical Innovation, v. 8, n. 41, p. 18-20, 2021.

LANAS-GIMENO A.; HIJOS, G.; LANAS, Á. Proton pump inhibitors, adverse events and increased risk of mortality. Expert Opinion on Drug Safety, v. 18, n. 11, p. 1043-1053, 2019.

LAZARUS, B.; CHEN, Y.; WILSON, F. P.; SANG, Y.; CHANG, A. R.; CORESH, J.; GRAMS, M. E. Proton pump Inhibitor use and the risk of chronic kidney disease. JAMA Internal Medicine, v. 176, p. 238–246, 2016.

LIMONGI, J.E.; OLIVEIRA, S.V. COVID-19 e a abordagem One Health (Saúde Única): uma revisão sistemática. Vigil. Sanit. Debate, v. 8, n. 3, p. 139-149, 2020.

LINDE, K.; JONAS, W.B.; MELCHART, D.; WORKU, F.; WAGNER, H.; EITEL, F. Critical review and meta-analysis of serial agitated dilutions in experimental toxicology. Hum Exp Toxicol, v.13, n.7, p.481-492, 1994.

LUCEY, M. R. Endogenous somatostatin and the gut. Gut, v. 27, n. 4, p. 457, 1986.

MAKUNTS, T.; ALPATTY, S.; LEE, K. C.; ATAYEE, R. S.; ABAGYAN, R. Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory. Scientific Reports, v. 9, n. 1, 2019.

MEDHURST, R. Indigestion: Background and management using homeopathy. Journal of the Australian Traditional-Medicine Society, v. 24, n.2, 2018.

MITTAL, R.; KHURANA, A.; GHOSH, M.S.; BAWASKAR, R.; TANEJA, D.; KASHYAP, S.; MANCHANDA, R.K. An open-label pilot study to explore usefulness of Homoeopathic treatment in nonerosive gastroesophageal reflux disease. Indian J. Res. Homoeopathy, v.10, p. 188-198, 2016.

MONNET, E. Anatomy and Physiology of the Stomach. Gastrointestinal Surgical Techniques in Small Animals.. Edited by Eric Monnet and Daniel D. Smeak, 2020.

MUKHERJEE, S.; JANA, T.; PAN, J.J. Adverse effects of proton pump inhibitors on platelet count: A case report and review of the literature. Case Reports in Gastrointestinal Medicine, v. 2018, 2018.

OGOSHI, K.; KATO, T.; SAITO, S.; NIWA, M.; WATANABE, H. Clinical study of AG-1749 (lansoprazole): Efects on serum gastrin levels and gastric mucosal ECL cell density. Yakuri to Chiryo, v. 19, p. 933–946, 1991.

OLIVEIRA, I.F.; PELUSO, B.H.B.; FREITAS, F.A.C.; DO NASCIMENTO, M.C. Homeopatia na Graduação Médica: Trajetória da Universidade Federal Fluminense. Rev. Bras. Educ. Med., v. 41, n. 2, p. 240-250, 2017.

PAGLIARO, G. E. Educação em saúde e homeopatia: uma perspectiva na educação popular e saúde. Revista APS, v. 11, n. 3, p. 249-263, 2008.

PASINA, L.; URRU, S. A.; MANDELLI, S.; GIUA, C.; MINGHETTI, P. Evidence-based and unlicensed indications for proton pump inhibitors and patients' preferences for discontinuation: a pilot study in a sample of Italian community pharmacies. Journal of Clinical Pharmacy and Therapeutics, v. 41, p. 220-223, 2016.

RANZINO, A. M.; SORRELLS, K. R.; MANOR, S. M. Possible acute thrombocytopenia post esomeprazole and hydantoin coadministration. Journal of Pharmacy Practice, v. 23, n. 2, p. 140–143, 2010.

RATNAPARIKH, P.; ADKINE, S.S. Management of peptic ulcer through homoeopathy. Journal of Medical and Pharmaceutical Innovation, v. 8, n. 39, p. 11-14, 2021.

ROSEN, R.; HU, L.; AMIRAULT, J.; KHATWA, U.; WARD, D. V.; ONDERDONK, A. 16S community profiling identifies proton pump inhibitor related differences in gastric, lung, and oropharyngeal microflora. The Journal of Pediatrics, v. 166, p. 917–923, 2015.

ROSS, M. H.; PAWLINA, W. Histologia: texto e atlas. Em correlação com biologia celular e molecular. Rio de Janeiro: Guanabara Koogan, 2014.

RUDELLI, A.; LEDUC, I.; TRAULLE, C.; SMAIL, A.; DUCROIX, J. P.; ANDRÉJAK, M.; BAILLET, J. Trombopenia following treatment with omeprazole. La Presse médicale, v. 22, n. 20, p. 966, 1993.

SAVARINO, V.; DULBECCO, P.; DE BORTOLI, N.; OTTONELLO, A.; SAVARINO, E. The appropriate use of proton pump inhibitors (PPIs): need for a reappraisal. European Journal of Internal Medicine, v. 37, p. 19–24, 2017.

SCHUBERT, M. L. Adverse effects of proton pump inhibitors: fact or fake news? Current Opinion in Gastroenterology, v. 34, n. 451–457, 2018.

ŞENEL, E. Evolution of homeopathy: A scientometric analysis of global homeopathy literature between 1975 and 2017. Complementary Therapies in Clinical Practice, v. 34, p. 165-173, 2019.

SHAMSI, B. H.; CHATOO, M.; XU, X. K.; XU, X.; CHEN, X. Q. Versatile functions of somatostatin and somatostatin receptors in the gastrointestinal system. Frontiers in Endocrinology, v. 16, n. 12, 2021.

STOJANOV, D. B.; KORAĆEVIĆ, G.; STOJANOV, D.; KORAĆEVIĆ, M.; IGNJATOVIĆ. N. Rebound phenomenon of proton pump inhibitor therapy. Acta Medica Medianae, v. 60, n. 2, p. 64-68, 2021.

TANAKA, M.; KATAOKA, H.; YAGI, T. Proton-pump inhibitor-induced fundic gland polyps with hematemesis. Clinical Journal of Gastroenterology, v.12, n. 2, p. 193-195, 2018.

TEIXEIRA, M. Z. Homeopatia: ciência, filosofia e arte de curar. Revista de medicina, v.85, n.2, p. 30-43, 2006.

ULLMAN, D. Exploring possible mechanisms of hormesis and homeopathy in the light of nanopharmacology and ultra-high dilutions. Dose-Response, v.19, n.2, p.1-13, 2021.

VANNIER, L.; POIRIER, J. Tratado de matéria médica homeopática. Editora Andrei, 9ª edição, 1987.

VARELA-CHINCHILLA, C. D.; SEGURA, N. Histology, Parietal Cells. [Updated 2021 May 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK547758/. Acesso em: 02 Fev, 2022.

VENKATESAN, H. Retrospective analytical case series study on the acid peptic disorders treated with homoeopathic medications. Research Journal of Pharmacology and Pharmacodynamics, v. 12, n. 2, p. 97 – 100, 2020.

WALDUM, H. L.; QVIGSTAD, G.; FOSSMARK, R.; KLEVELAND, P. M.; SANDVIK, A. K. Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint. Scandinavian Journal of Gastroenterology, v. 45, p. 389-394, 2010.

WALDUM, H. L.; SAGATUN, L.; MJONES, P. Gastrin and gastric cancer. Frontiers in Endocrinology (Lausanne), v. 8, n. 1, 2017.

WILSON, R. L.; STEVENSON, C. E. Anatomy and physiology of the stomach. In: _____________. Shackelford’s Surgery of the Alimentary Tract (eds. C.J. Yeo et al.), p. 634–646. Philadelphia: Elsevier, 2019.

XIAN, Y.; ZHAO, X.; WANG, C.; KANG, C.; DING, L.; ZHU, W.; HANG, S. Phenylalanine and tryptophan stimulate gastrin and somatostatin secretion and H+-K+-ATPase activity in pigs through calcium-sensing receptor. General and Comparative Endocrinology, v. 267, p. 1-8, 2018.

XIE, Y.; BOWE, B.; YAN, Y.; XIAN, H.; LI, T.; AL-ALY, Z. Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study. The BMJ, v. 365, 2019

YAO, X.; SMOLKA, A. J. Gastric parietal cell physiology and Helicobacter pylori–induced disease. Gastroenterology, n.156, p. 2158–2173, 2019.

ZLABEK, J. A.; ANDERSON, C. G. Lansoprazole-induced thrombocytopenia. Annals of Pharmacotherapy, v. 36, n. 5, p, 809–811, 2002.