Humic Substances: Possibility of New Therapeutic Application
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Published:
Jan 16, 2009
Keywords:
Humic substances, Potentially toxic metals, Chelating agents. Substâncias húmicas, Metais potencialmente tóxicos, Agentes quelantes.
Main Article Content
Abstract
Humic substances (HS) are heterogeneous molecular aggregates, which have no defined structure and constitute the principal fraction of natural organic matter. They can act as complexation agents, due to their high density of functional groups, and therefore directly influence the transport, accumulation, bioavailability and toxicity of different substances. Metals are important environmental pollutants, since they are widely used during human activities, and following release are not either chemically or biologically degraded. Treatment of acute poisoning in humans caused by potentially toxic metals has employed complexation agents such as ethylenediaminetetraacetic acid (EDTA) or -aminoacids. However, some limitations of these materials such as the lack of selectivity of EDTA and the high cost of -aminoacids have provided the incentive for a search for alternatives. Previous studies of the properties of HS indicate their possible use as an alternative to these chelanting agents.
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How to Cite
Ferreira, N. N., dos Santos, A., Ribeiro, M. L., Oliveira, L. C. de, Botero, W. G., & Rocha, J. C. (2009). Humic Substances: Possibility of New Therapeutic Application. Revista Brasileira Multidisciplinar, 12(2), 205-226. https://doi.org/10.25061/2527-2675/ReBraM/2009.v12i2.168
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• Publishers have the right to make textual adjustments and to adapt the article to the rules of publication.
Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg publish in institutional repository or as book chapter), with acknowledgment of authorship and initial publication in this journal.
Authors are allowed and encouraged to publish and distribute their work online (eg in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and citation of the published work (See The Effect of Free Access) at http://opcit.eprints.org/oacitation-biblio.html
