Use of Calendula officinalis in Wound Healing: An Overview
Article Sidebar
Main Article Content
Abstract
The history of medicinal plants is as long as the history of mankind. Medicinal plants are important sources of chemical substances that have beneficial therapeutic effects on human health. Calendula officinalis is a plant that has been used for centuries as a herbal medicine, especially in wound healing. The use of C. officinalis as a healing agent has already been supported by different in vivo and in vitro studies. Thus, the objective of this review is to provide an overview of current studies on the effect of Calendula on wound healing. The search for studies occurred in three databases, considering only studies from the last five years. This review included 03 in vitro studies, 04 in vivo studies in animal models and 04 clinical ones. Evidence suggests that C. officinalis may be an important source for the development of new effective healing drugs.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
• The author (s) warrant that the contribution is original and unpublished and that it is not in the process of being evaluated in other journal (s);
• The journal is not responsible for the opinions, ideas and concepts issued in the texts, as they are the sole responsibility of the author (s);
• Publishers have the right to make textual adjustments and to adapt the article to the rules of publication.
Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg publish in institutional repository or as book chapter), with acknowledgment of authorship and initial publication in this journal.
Authors are allowed and encouraged to publish and distribute their work online (eg in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and citation of the published work (See The Effect of Free Access) at http://opcit.eprints.org/oacitation-biblio.html
References
ABDELWAHAB, S. I. et al. Fifty-year of Global Research in Calendula Officinalis L. (1971−2021): A Bibliometric Study. Clinical Complementary Medicine and Pharmacology, v. 2, n. 4, p. 100059, 1 dez. 2022.
ANDRITOIU, C. V. et al. Effects and Characterization of Some Topical Ointments Based on Vegetal Extracts on Incision, Excision, and Thermal Wound Models. Molecules (Basel, Switzerland), v. 25, n. 22, p. 5356, 16 nov. 2020.
ARO, A. A. et al. Effect of Calendula officinalis cream on achilles tendon healing. Anatomical Record (Hoboken, N.J.: 2007), v. 298, n. 2, p. 428–435, fev. 2015.
ARORA, D. et al. A Review on Phytochemistry and Ethnopharmacological Aspects of Genus Calendula. Pharmacognosy Review, v. 7, n. 14, p. 187, 2013.
BAHRAMSOLTANI, R.; FARZAEI, M. H.; RAHIMI, R. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Archives of Dermatological Research, v. 306, n. 7, p. 601–617, set. 2014.
BALBINO, C. A.; PEREIRA, L. M.; CURI, R. Mecanismos envolvidos na cicatrização: uma revisão. Revista Brasileira de Ciências Farmacêuticas, v. 41, p. 27–51, mar. 2005.
BOSCH–NUÑEZ, A. I. et al. Aplicación de una jalea de caléndula al 1% en pacientes con alveolitis. Acta Odontológica Colombiana, v. 11, n. 2, p. 39–47, 2021.
CARVALHO, A. R. et al. Use of Some Asteraceae Plants for the Treatment of Wounds: From Ethnopharmacological Studies to Scientific Evidences. Frontiers in Pharmacology, v. 9, 2018.
CARVALHO, A. F. M. DE et al. Low-level laser therapy and Calendula officinalis in repairing diabetic foot ulcers. Rev. Esc. Enferm. USP, p. 628–634, 2016.
CHANAJ-KACZMAREK, J. et al. Hydrogel Delivery System Containing Calendulae flos Lyophilized Extract with Chitosan as a Supporting Strategy for Wound Healing Applications. Pharmaceutics, v. 12, n. 7, p. 634, 7 jul. 2020.
CITADINI-ZANETTE, V.; NEGRELLE, R.; BORBA, E. Calendula officinalis L. (ASTERACEAE): ASPECTOS BOTÂNICOS, ECOLÓGICOS E USOS. Visão Acadêmica, v. 13, 28 nov. 2012.
DINDA, M. et al. PI3K-mediated proliferation of fibroblasts by Calendula officinalis tincture: implication in wound healing. Phytotherapy research: PTR, v. 29, n. 4, p. 607–616, abr. 2015.
FARHAN, A. et al. Evaluation and HPLC characterisation of a new herbal ointment for the treatment of full-thickness burns in rats. Journal of Taibah University Medical Sciences, v. 16, n. 2, p. 152–161, abr. 2021.
FERREIRA, A. S. et al. Natural Products for the Prevention and Treatment of Oral Mucositis—A Review. International Journal of Molecular Sciences, v. 23, n. 8, p. 4385, jan. 2022.
FRONZA, M. et al. Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts. Journal of Ethnopharmacology, v. 126, n. 3, p. 463–467, 10 dez. 2009.
GIOSTRI, G. S. et al. Treatment of acute wounds in hand with Calendula officinalis L.: A randomized trial. Tissue Barriers, v. 10, n. 3, p. 1994822, 3 jul. 2022.
GULER, E. et al. Bio-active nanoemulsions enriched with gold nanoparticle, marigold extracts and lipoic acid: In vitro investigations. Colloids and Surfaces B: Biointerfaces, v. 121, p. 299–306, 1 set. 2014.
HORMOZI, M. et al. Calendula officinalis stimulate proliferation of mouse embryonic fibroblasts via expression of growth factors TGFβ1 and bFGF. Inflammation and Regeneration, v. 39, n. 1, p. 7, 20 abr. 2019.
IONESCU, O. M. et al. New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation. Polymers, v. 13, n. 8, p. 1291, jan. 2021.
IZADI, K.; GANCHI, P. Chronic wounds. Clinics in Plastic Surgery, v. 32, n. 2, p. 209–222, abr. 2005.
JAHDI, F. et al. The impact of calendula ointment on cesarean wound healing: A randomized controlled clinical trial. Journal of Family Medicine and Primary Care, v. 7, n. 5, p. 893–897, 2018.
JARIĆ, S. et al. Traditional wound-healing plants used in the Balkan region (Southeast Europe). Journal of Ethnopharmacology, v. 211, p. 311–328, 30 jan. 2018.
KAUR, J. et al. Calendula officinalis ameliorates l-arginine-induced acute necrotizing pancreatitis in rats. Pharmaceutical Biology, v. 54, n. 12, p. 2951–2959, 1 dez. 2016.
LAHMAR, A. et al. Design of 3D Hybrid Plant Extract/Marine and Bovine Collagen Matrixes as Potential Dermal Scaffolds for Skin Wound Healing. The Scientific World Journal, v. 2022, p. e8788061, 30 jun. 2022.
MIDDLETON, E.; KANDASWAMI, C.; THEOHARIDES, T. C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Reviews, v. 52, n. 4, p. 673–751, dez. 2000.
MORESKI, D. A. B.; LEITE-MELLO, E. V. DE S.; BUENO, F. G. Ação cicatrizante de plantas medicinais: um estudo de revisão. Arq. ciências saúde UNIPAR, p. 63–69, 2018.
MULEY, B. P.; KHADABADI, S. S.; BANARASE, N. B. Phytochemical Constituents and Pharmacological Activities of Calendula officinalis Linn (Asteraceae): A Review. Tropical Journal of Pharmaceutical Research, v. 8, n. 5, 2009.
NAKAMURA-GARCÍA, A. K. et al. Healing of Wounds Treated with Chitosan Hydrogels with Extracts from Aloe vera and Calendula officinalis. Mexican Journal of Biomedical Engineering, v. 43, n. 1, p. 19–31, 25 abr. 2022.
NICOLAUS, C. et al. In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts. Journal of Ethnopharmacology, v. 196, p. 94–103, 20 jan. 2017.
OKUMA, C. H. et al. Development of lamellar gel phase emulsion containing marigold oil (Calendula officinalis) as a potential modern wound dressing. European Journal of Pharmaceutical Sciences, v. 71, p. 62–72, 25 abr. 2015.
OLIVEIRA, A. C. DE et al. Qualidade de vida de pessoas com feridas crônicas. Acta Paulista de Enfermagem, v. 32, p. 194–201, 10 jun. 2019.
PARENTE, L. M. L. et al. Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil. Evidence-Based Complementary and Alternative Medicine: eCAM, v. 2012, p. 375671, 2012.
REZAI, S. et al. Effect of oral Calendula officinalis on second-degree burn wound healing. Scars, Burns & Healing, v. 9, p. 20595131221134053, 2023.
VELNAR, T.; BAILEY, T.; SMRKOLJ, V. The wound healing process: an overview of the cellular and molecular mechanisms. The Journal of International Medical Research, v. 37, n. 5, p. 1528–1542, 2009.
WU, X. X. et al. Effects of topical application of a tri-herb formula on inflammatory dry-skin condition in mice with oxazolone-induced atopic dermatitis. Phytomedicine, v. 91, p. 153691, 1 out. 2021.