Atividade antidiabética das macroalgas pardas do gênero Sargassum - Uma revisão
Article Sidebar
Main Article Content
Abstract
Diabetes mellitus is a chronic metabolic syndrome characterized by the insistent rising of blood sugar levels. Pharmacologic therapy includes insulin administration and oral hypoglycemic medications which have side effects such as hypoglycemia and gastrointestinal disorders and are not always effective in preventing and treating diabetes complications. The search for natural alternatives is a promising strategy in the treatment of chronic diseases. Brown macroalgae of the genus Sargassum has shown a range of secondary metabolites with several biological activities, such as anti-inflammatory, antitumoral, antimicrobial, neuroprotective, hypolipidemic and hypoglycemic activity. Therefore the aim of this work was to carry out a literature review of the antidiabetic activity of Sargassum spp. Either extracts or isolated compounds/fractions of compounds of these algae could reduce diabetes symptoms through various mechanisms, such as in vitro inhibition of the key enzymes in polysaccharides breakage, α-amylase and α-glucosidase, and the reduction of insulin resistance, providing the amelioration of the hyperglycemic condition. Thus Sargassum spp and their bioactive compounds have a great potential in the treatment of diabetes and prevention of the micro and macrovascular complications resulting from sustained hyperglycemic state.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
• The author (s) warrant that the contribution is original and unpublished and that it is not in the process of being evaluated in other journal (s);
• The journal is not responsible for the opinions, ideas and concepts issued in the texts, as they are the sole responsibility of the author (s);
• Publishers have the right to make textual adjustments and to adapt the article to the rules of publication.
Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg publish in institutional repository or as book chapter), with acknowledgment of authorship and initial publication in this journal.
Authors are allowed and encouraged to publish and distribute their work online (eg in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and citation of the published work (See The Effect of Free Access) at http://opcit.eprints.org/oacitation-biblio.html
