Quality Analysis of Different Brands of Captopril Table

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Published: Jul 10, 2014
DOI: https://doi.org/10.25061/2527-2675/ReBraM/2014.v17i2.31
Keywords:
Quality Control, Analysis, Captopril. Controle de qualidade, Análise, Captopril.

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Samyra Leandro Domiciano
Centro Universitário de Votuporanga/Campus Centro.
Sandra Ramos Farias
Centro Universitário de Votuporanga/Campus Centro.
Christiane Oliveira Jordão
Centro Universitário de Votuporanga/ Campus Centro.

Abstract

Quality control consists of a set of operations in order to verify if the product conforms to the specifications of the pharmacopoeia, to assure its safety, its therapeutic efficacy and its quality, throughout the validity period. For the patient, the lack of quality of the product causes serious trouble with health risks. The annual consumption of antihypertensive drugs rose from January 2010 to April 2013, an increase of 41.1 million to 119 million units, with 16.57% share of sales attributable to drugs to control blood pressure in which captopril represents 1.47%. Considering these data, the present study aimed at quantifying the content of captopril tablets of different brands available in the pharmaceutical market. Analyses were performed with 25 mg tablets of six different laboratories, being three similar and three generic ones. The analysis methodology was based on titrimetric method, determining the individual and mean weight of the tablets analyzed, as shown in the official methodology. Duplicate analyzes were performed. The data were statistically evaluated by determining the coefficient of variation and standard deviation. Despite the analyzed brands present statistical differences, it is possible to confirm that the tests of all samples were within the established standards.

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How to Cite
Domiciano, S. L., Farias, S. R., & Jordão, C. O. (2014). Quality Analysis of Different Brands of Captopril Table. Revista Brasileira Multidisciplinar, 17(2), 107-115. https://doi.org/10.25061/2527-2675/ReBraM/2014.v17i2.31
Issue
Vol. 17 No. 2 (2014): Julho/dezembro
Section
Artigos Originais
 
 
 
 
1437/5000
 
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Author Biographies

Samyra Leandro Domiciano, Centro Universitário de Votuporanga/Campus Centro.

Discente do Curso de Farmácia do Centro Universitário de Votuporanga/Campus Centro.

Sandra Ramos Farias, Centro Universitário de Votuporanga/Campus Centro.

Discente do Curso de Farmácia do Centro Universitário de Votuporanga/Campus Centro.

Christiane Oliveira Jordão, Centro Universitário de Votuporanga/ Campus Centro.

Docente do Curso de Farmácia do Centro Universitário de Votuporanga/ Campus Centro.
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