Comparative Study Capsules Containing Amoxicillin Obtained Some of Magistral Pharmacies
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Published:
Jul 15, 2011
Keywords:
Amoxicillin capsules, Pharmacies, Quality control. Cápsulas de amoxicilina, Farmácias magistrais, Controle de qualidade.
Main Article Content
Abstract
Amoxillin is a semisynthetic antibiotic classified as penicillin of wide action spectrum against gram-positive and gram-negative bacteria, largely used in the treatments of several infections. Besides, amoxicillin is a drug widely used in clinical treatment (the usual dosage is 500 mg). According to RDC n.87/2008, in order to monitoring the manipulation process, pharmacies must analyze their pharmaceutical formulations to assure some important quality parameters, such as average weight, dissolution time and assay, to guarantee the drug concentration and therapeutic efficacy. The objective of this work was to develop a comparative study of three pharmaceutic formulations containing amoxicillin 500 mg (capsules) and to compare the results to those obtained from the generic drug. The analysis was carried out according to Brazilian Pharmacopoeia for amoxicillin. Although the 3 magistral preparations analyzed have been approved in average weight determination, only one pharmaceutical formulation presented satisfactory results for time dissolution and assay determinations (81,30 ± 0,98% and 91,65 ± 0,72%, respectively). The results showed the necessity of a strict quality monitoring by the pharmacies to assure the correct drug dosage and its therapeutic efficacy. The selection of excipients and the weight, blend and encapsulation procedures are very important, as well as the evaluation of the purity and integrity of raw materials.
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How to Cite
Paulo, G. dias, Mazzuco, A. P., Rodolpho, J. C., Salgado, H. R. N., & Moreno, A. de H. (2011). Comparative Study Capsules Containing Amoxicillin Obtained Some of Magistral Pharmacies. Revista Brasileira Multidisciplinar, 14(2), 50-60. https://doi.org/10.25061/2527-2675/ReBraM/2011.v14i2.111
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Artigos Originais
1437/5000
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• The author (s) warrant that the contribution is original and unpublished and that it is not in the process of being evaluated in other journal (s);
• The journal is not responsible for the opinions, ideas and concepts issued in the texts, as they are the sole responsibility of the author (s);
• Publishers have the right to make textual adjustments and to adapt the article to the rules of publication.
Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg publish in institutional repository or as book chapter), with acknowledgment of authorship and initial publication in this journal.
Authors are allowed and encouraged to publish and distribute their work online (eg in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and citation of the published work (See The Effect of Free Access) at http://opcit.eprints.org/oacitation-biblio.html
