Effect of Dipyrone, Naproxen and Diclofenac Potassium on Blood Cells
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Published:
Jan 16, 2009
Keywords:
Leukocytes, Agranulocytosis, NSAIDs, Dipyrone, Hematology Leucócitos, Agranulocitose, Anti-inflamatórios não esteroidais, Dipirona, Hematologia.
Main Article Content
Abstract
In therapy, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat mild conditions and severe musculoskeletal disorders. However, some effects may occur due to their use, such as agranulocytosis, leukopenia and aplastic anemia. Objectives: to evaluate the effect of some NSAIDs on leukocyte production; to evaluate possible modification of the granules of neutrophils and to compare the total leukocyte count, by using manual and automated methods. 42 samples of whole blood of female rats, Wistar race, were analyzed in this experiment. The animals ingested solutions of diclofenac (DC), dipyrone (DP) and naproxen (NX), in two concentrations: the therapeutic plasma and another ten times more concentrated, for 5 days. We performed differential counts on stained smear and leukocytes were counted using manual methods with the Neubauer counting chamber and automated method (Coulter T-890). The comparison between the methods presented no significant differences in any analyzed group. Regarding to the overall number of leukocytes, no significant changes between the groups were observed. Regarding to the differential count we observed a significant increase in the number of atypical lymphocytes found in the group treated with diluted DP. This study demonstrated that dipyrone: 1) served as a toxic agent due to lymphocyte activation and the large number of neutrophils with nuclear pyknosis; 2) the Coulter T-890 can be used for total leukocyte count of animals; 3 ) other anti-inflammatory drugs studied did not cause abnormalities.
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How to Cite
Ariede, J. R., Perilio, L., Ballestero, L. G. B., & Gileno, M. da C. (2009). Effect of Dipyrone, Naproxen and Diclofenac Potassium on Blood Cells. Revista Brasileira Multidisciplinar, 12(2), 89-100. https://doi.org/10.25061/2527-2675/ReBraM/2009.v12i2.160
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• Publishers have the right to make textual adjustments and to adapt the article to the rules of publication.
Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg publish in institutional repository or as book chapter), with acknowledgment of authorship and initial publication in this journal.
Authors are allowed and encouraged to publish and distribute their work online (eg in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and citation of the published work (See The Effect of Free Access) at http://opcit.eprints.org/oacitation-biblio.html
